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KMID : 0358419950380061048
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Korean Journal of Obstetrics and Gynecology
1995 Volume.38 No. 6 p.1048 ~ p.1054
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Clinical Significance of Flow Cytometric Analysis of DNA Content in Epithelial Ovarian Cancer
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문준
이상희/김해중/이규완/구병삼/김인선
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Abstract
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We investigated the clinical significance of DNA content and proliferative activity or tumor cell populations as flow cytometry analysis from twenty epithelial malignant tumors of the ovary and seven boderline malignant tumors of the ovary.
The DNA aneuploidy was found in nine cases of twenty malignant epithelial tumors (45.0%) of the ovary and one case of seven boderline tumors of the ovary(14.3%).
The S-phase fraction (SPF) of malignant ovarian tumor(11.9±5.7%) was significantly higher than that of boderline ovarian tumor(6.5±6.0%).
The DNA aneuploidy and S-phase fraction were significantly correlated with FIGO stage and tumor grade. The DNA aneuploidy rate and S-phase fraction were higher in the advanced and poorly differentiated epithelial malignant ovarian tumors.
Analyzing the result of flow cytometry, the malignant epithelial ovarian tumors were separated into the three groups, aneuploidy group with a SPF greater than 18%, aneuploidy group with a SPF less than 18% and diploidy group. All cases of the
aneuploidy
group with a SPF greater than 18% showed advanced stage(strage III-IV) and poorly differentiated grade(grade III).
From our results, we suggested that the flow cytometric DNA pattern correlate with the aggresive potential of a malignant epithelial ovarian tumor and provide additional information about tumor prognosis.
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KEYWORD
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